there is a blogger who just recently became JC + and still takes Tysabri, it's MATTSMS. . . do your research, the JC virus + doesn't mean you have to stip Tysabri or mean that you will get PML, just means you have to re-evaluate and monitor your symptoms more closely. I love the way I feel now I take Tysabri compared to when I was on Copaxone. hugs

There is now an index or a range of how positive you can be for the JC virus. If you test low on the index scale you can continue on Tysabri. The lower index does increase your chance of PML but it's still a very small statistic. If you start testing higher on the index that's when you and your dr. will make the decision to continue or not based on how susceptible you might be to PML.

Smooth, almost EVERYONE

Don't take the chance of staying on Tysabri if you've tested positive for the JC virus. It's a game of Russian Roulette.

I agree with @A MyMSTeam Member. I read and Immunologist I saw confirmed that even if JC positive, there is almost no chance to develop PML for the first two years on Tysabri. Its the go-to treatment at their clinic for MS because it has the best long-term outcome in studies, and they see great outcomes clinically. For me though, they recommended Aubagio so we could manage other autoimmune disease activity too.

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