I had the same reaction, and after getting no help from Plegridy or my Neuo, I decided to try something. It occurred to me that maybe I was allergic to the carrier fluid they are using, so I started taking an OTC allergy pill a hour before injecting the shot (I like Zyrtec). Here is how I set up & take my shots: I take a Zyrtec first thing, then 30 mins later I take the shot out and warm it to body temperature by putting the shot under my arm, then I inject. I haven't had any site reactions now for about 6 months.

Suzette - do you take the Zyrtec for a few days, or just the one time?

I warmed my Plegridy injection to body temperature and still had the same reaction. I didn't use Zyrtec I used the Benadryl. I'm will try the Zyrtec in the near future to see if it makes a difference or not.

Yes, @A MyMSTeam Member, I was worried this was going to be a permanent thing for me. I had finally gotten away from taking shots EOD, and was upset that I would have to settle for having spots everywhere! I told my doctor I was going to look like a giraffe in a couple months! lol....so glad I found something that works, that was also simple to use.

Oh, and for @A MyMSTeam Member, I only use it prior to the shot, unless I am having other allergy issues.

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A MyMSTea...

A MyMSTea...

I started Plegidy in April 2015, and have had the same experience. It occurred to me this is similar to a histamine reaction, and since I take antihistamines at times throughout the year I decided to try taking a Zyrtec 2 hours prior to my injection, and it works wonderfully. I have done this three times now and do not have any red spots, swelling, hot spots, or pain. Oh, and a nurse suggested warming the shot to body temperature instead of room temperature, so now I put my shot under my arm for 5-0 mins before injecting. Hope this helps.