I have, but I think it's best to find something to get on and stay on but I've always had bad side effects to ms meds so I've been on and off them for years. I'm currently on Tysabri and it's going well. The down side is that you can only take Tysabri for a couple of years because of the risk of JC virus. Anyway, i was off meds for a while but don't recommend it I do wish you luck.