Hello. I have been taking ZINBRYTA since 2011 and have had no major side effects or issues. I was originally in the study for the medication when it began in 2011. I am no longer in the study, it's over, now I am taking it since its been approved buy the FDA. Diagnosed in 1992, major excaserbation in 2010, home bound for a year, joined the study and here I am. ZINBRYTA seems to be working for me.