Tried both. Cymbalta made me very nauseous, so bad i was scared to move! I think it may be a reaction to Avonex but not trying that again!
Wellbutrin took the edge off, sure, but made me eat and sleepy at times. I dont take anything now.

Cymbalta did nothing for my pain. I was very disappointed. Wellbutrin made me hyper and I had a seizure from taking it. It's supposed to help you quit smoking, too. Should be helpful if you have fatigue, too.

I have never heard of Wellbutrin for fatigue, I took it for years for depression.

I take elavil (pain/depression), Zoloft and cymbalta. Don't know if I would have survived without these. Started with the elavil in 1991 and Zoloft and cymbalta were added through the years.

I took the Wellbutrin for a year and I saw no difference in fatigue levels so I quit taking it