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Mitoxantrone is used mainly to treat metastatic breast cancer but is also used to treat multiple sclerosis (MS), most notably the subset of the disease known as secondary-progressive MS. In the absence of a cure, mitoxantrone is effective in slowing the progression of secondary-progressive MS and extending the time between relapses in both relapsing-remitting MS and progressive-relapsing MS.

November 19, 2018
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A MyMSTeam Member

I dont know..cancer treating drugs are Scary to me, but if its an option, do your research! Ask pharmacists..they are the experts.

November 19, 2018 (edited)
A MyMSTeam Member

You should ask your pharmacists,I think would be a good idea.

November 20, 2018
A MyMSTeam Member

I have secondary progressive MS but I hve never been prescribed Novantrone.

November 19, 2018
A MyMSTeam Member

Mitoxantrone is a type II topoisomerase inhibitor; it disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells by intercalation een DNA bases.

In picture: Human topoisomerase II beta in complex with DNA and mitoxantrone. PDB entry 4g0v.[5] Detail showing mitoxantrone (spheres) intercalated with DNA.

November 19, 2018

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