Neurogenic detrusor overactivity (NDO) can result in lower and upper urinary tract complications and eventually even in end-stage kidney failure. Since the driving force of this clinical cascade is high bladder pressure, controlling intravesical pressure in NDO patients improves both quality of life and life-expectancy in these patients. Botulinum toxin A (BTX-A) has proven its efficacy in reducing intravesical pressure and in reducing incontinence episodes. BTX-A also improves quality of life in patients with NDO. Both onabotulinumtoxinA (Botox®, Allergan, Irvine, USA) and abobotulinumtoxinA (Dysport®, Ipsen, Paris, France) have a level A recommendation for NDO-treatment. The recommended dose for intradetrusor injections in NDO patients is 200 U of onabotulinumtoxinA or 500 U of abobotulinumtoxinA. The drug is generally administered extratrigonal in the detrusor muscle, via cystoscopic guided injection at 20 sites in 1 mL injections. Intradetrusor BTX-A injections are safe, with mostly local complications such as urinary tract infection and high post-void residual or retention. The effect of the toxin lasts for approximately 9 months. Repeat injections can be performed without loss of efficacy. Different injection techniques, novel ways of BTX-A administration, eliminating the need for injection or new BTX-A types with better/longer response rates could change the field in the future.

I do Botox injections for the spasticity in my right thigh and a some in my lower leg.It's not a 100% cure but it's been pretty helpful!

MSF 31 BOTOX and MS
I hope this helps.
Description
Onabotulinumtoxin A (BOTOX) is a powerful neurotoxin that temporarily blocks connections between the nerves and the muscles, resulting in short-term relaxation of the targeted muscle. Botox is administered by injection.
BOTOX is approved by the U.S. Food and Drug Administration (FDA) to treat:
• Upper limb spasticity in adults, to relieve increased muscle tone in elbow flexors (biceps), wrist flexors, and finger flexors, including thumb flexor muscles. Upper limb spasticity can occur in MS as well as other disorders.
• Lower limb spasticity in adults, to relieve increased muscle tone in ankle and toe flexors. Lower limb spasticity can occur in MS as well as other disorders.
• urinary incontinence resulting from over activity of the bladder detrusor muscle caused by MS or other neurologic condition, in adults who have an inadequate response to anticholinergic medications or are unable to tolerate them.
Injection of the bladder muscle with Botox is performed using cystoscopy, a procedure that allows a doctor to visualize the interior of the bladder. Cystoscopy may require general anesthesia.

Support
BOTOX Patient Assistance Program:
1-800-44-BOTOX (1-800-442-6869)
www.botox.com/
Financial Assistance Program
BOTOX Reimbursement Program
www.botox.com/