Progressive MS, including Primary Progressive MS (PPMS) and Secondary Progressive MS (SPMS), involves a steady worsening of symptoms and disability over time. Here are some key points:
Primary Progressive MS (PPMS)
- Progression: Symptoms worsen progressively without clear relapses or periods of remission
- Disability: Show Full Answer
Progressive MS, including Primary Progressive MS (PPMS) and Secondary Progressive MS (SPMS), involves a steady worsening of symptoms and disability over time. Here are some key points:
Primary Progressive MS (PPMS)
- Progression: Symptoms worsen progressively without clear relapses or periods of remission.
- Disability: Neurological function and disability worsen over time.
- Lesions: More spinal cord lesions than brain lesions, leading to increased motor symptoms like difficulty walking.
- Classification:
- Inactive without progression: Symptoms aren’t worsening, and no advancement in disability milestones.
- Inactive with progression: No new symptoms or lesions, but disability is progressing.
- Active without progression: Symptoms may worsen or new symptoms may develop, but no disability progression.
- Active with progression: New or worsening symptoms, new lesions, and increased disability over the past 12 months.
Secondary Progressive MS (SPMS)
- Transition: Develops from relapsing-remitting MS (RRMS) and involves fewer relapses but increased nerve damage.
- Progression: Steady worsening of neurological function and increased disability.
- Risk: 50% of people with RRMS transition to SPMS within 10 years, and 90% within 25 years.
- Symptoms: Increased MS symptoms, which may be gradual or rapid.
General Notes
- Diagnosis: It may take longer to diagnose PPMS compared to RRMS.
- Treatment: Disease-modifying therapies (DMTs) can help manage symptoms and slow progression.
For more detailed information, you can refer to the specific articles on MyMSTeam:
- [Types of MS: Breaking Down the Rare and Common Stages of MS](https://www.mymsteam.com/resources/multiple-scl...)
- [Secondary Progressive Multiple Sclerosis Explained](https://www.mymsteam.com/resources/secondary-pr...)
- [Primary Progressive MS Symptoms: Fatigue, Mood Changes, and More](https://www.mymsteam.com/resources/symptoms-of-...)
- [Signs and Symptoms of Secondary Progressive Multiple Sclerosis (SPMS)](https://www.mymsteam.com/resources/signs-and-sy...)
July 13, 2024
Join
Your Privacy Choices
