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June 27, 2025
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10 Signs and Symptoms of SPMS: Pain, Numbness, Walking Issues, and More Read Article...
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Primary Progressive MS (PPMS) symptoms typically include:

• Motor difficulties with walking and standing
• Pain (headaches, leg/foot pain, back pain, muscle spasms)
• Electric-shock sensations (Lhermitte sign)
• Vision problems
• Muscle weakness
• Balance issues
• Numbness and tingling
• Dizziness
• Cognitive difficulties Show Full Answer

Primary Progressive MS (PPMS) symptoms typically include:

• Motor difficulties with walking and standing
• Pain (headaches, leg/foot pain, back pain, muscle spasms)
• Electric-shock sensations (Lhermitte sign)
• Vision problems
• Muscle weakness
• Balance issues
• Numbness and tingling
• Dizziness
• Cognitive difficulties
• Mood changes

PPMS causes more spinal cord lesions than brain lesions, which is why motor functions are often more affected. The key difference between types:

PPMS shows steady progression from onset without any remissions or relapses. RRMS has distinct episodes of symptoms (relapses) followed by periods of recovery (remissions). SPMS develops only in people who previously had RRMS, representing a phase where symptoms gradually worsen with increased disability, though some may still experience occasional relapses.

June 27, 2025

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