What are the side effects of Ocrevus?
Ocrevus (ocrelizumab) is a B-cell depleting therapy used to treat both relapsing forms of MS and primary progressive MS. Understanding potential side effects can help you prepare for treatment.
Common side effects related to infusions include:
* Infusion reactions (which can be Show Full Answer
What are the side effects of Ocrevus?
Ocrevus (ocrelizumab) is a B-cell depleting therapy used to treat both relapsing forms of MS and primary progressive MS. Understanding potential side effects can help you prepare for treatment.
Common side effects related to infusions include:
* Infusion reactions (which can be reduced with premedication like Benadryl, Tylenol, and steroids)
* Fatigue and drowsiness, especially from the Benadryl pretreatment
* Feeling tired for a day or two after the infusion
Many MyMSTeam members report needing rest after their infusions and plan light activities for the following days.
The "Crap Gap"
Some people experience worsening symptoms before their next scheduled dose, commonly called the "crap gap." This can include:
* Extreme fatigue
* Brain fog or cognitive issues
* Balance problems
* Tingling or pins-and-needles sensations
Impact on Immune Response
Since Ocrevus suppresses B-cells to control MS, it may result in a smaller antibody response to vaccines. However, your T-cell response typically remains strong. This is something to discuss with your neurologist, especially when planning vaccinations.
Staying well-hydrated before and during infusions can help reduce side effects. Talk to your doctor about any concerns or if you've had reactions to premedications in the past.
November 18, 2025
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