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What side effects or odd things does anybody have when they're having infusions.

A MyMSTeam Member asked a question 💭
Amelia, OH

For me during and after my infusions. Feels like something is crawling all over my skin. Weird

November 30, 2025
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A MyMSTeam Member

When I used to have my Ocrevus Infusions I didn’t have any issues but when I went to get my annual mammogram they spotted something so of course I had to go through all the different tests and go through surgery to have a complete mastectomy on both breasts because I was DCSI pre cancerous. So I decided to just get rid of my breasts in case it became breast cancer. Now I cannot take Ocrevus anymore because of that.. ocrevus kept me stable I didn’t have any new lesions in years and I haven’t had any relapses in a few years. Oh well. Now my neurologist wants to try Mayzent on me it’s going to be awhile before I get to talk with her since I can’t get in until March 2026. So I’ve been off any medication since April of 2025 but I’ve actually feeling ok and hope I stay that way. I’m kinda nervous about Mayzent I’ve seen some good and some bad. We shall see.

December 5, 2025
MyMSTeam

What side effects or unusual sensations do people experience during and after MS infusions?

That crawling sensation on your skin isn't weird at all - it's actually reported by quite a few people with MS! This feeling of bugs crawling on the skin is one of the more unusual sensations described by those living with MS, and Show Full Answer

What side effects or unusual sensations do people experience during and after MS infusions?

That crawling sensation on your skin isn't weird at all - it's actually reported by quite a few people with MS! This feeling of bugs crawling on the skin is one of the more unusual sensations described by those living with MS, and it can affect the face, arms, legs, or torso.

During infusions, some common side effects can include:

* Itchy skin or hives
* Headache
* Fever or chills
* Pain or swelling at the injection site
* Difficulty breathing (in rare cases)

These reactions can happen because your body may view the medication as a threat, triggering an immune response.

After infusions, many people report feeling tired or drowsy, especially if they received premedication like Benadryl. Some describe needing to take a "Benadryl nap" and planning light, low-energy days following their treatment. Fatigue can last a couple of days for some people.

If you're experiencing this crawling sensation during and after your infusions, it's worth mentioning to your healthcare team. They need to know about any side effects you're experiencing, even if they seem mild, so they can monitor you appropriately and make any necessary adjustments to prevent future reactions.

Staying well-hydrated before and during your infusion can actually help reduce some common side effects, so make sure you're drinking plenty of fluids in the days leading up to your treatment.

November 30, 2025
A MyMSTeam Member

Sorry, no I've never felt that.

December 1, 2025

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