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Starting Siponimod at 62.....

A MyMSTeam Member asked a question 💭
Gloucester, UK

I think I am 'borderline' SP/PP (diagnosed in my early 40's), and I am being prescribed at this very moment meds for mainly fatigue, bladder control and mobility.... As my EDSS has reduced with 0.5 over the last years, I am now 'eligible' for Siponimod.... (btw a recent repeat MRI did not show a lot of change over a significant number of years).
I don't really know what to expect, and I just wonder if any of you recognise themselves in the 'MS loop' I have been in so far?

December 1, 2025
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A MyMSTeam Member

Hello All, well I'm 64 with Clinically Isolated Syndrome MS,been on copaxone, and was allergic to it,now Avonex, Praying when I turn 65 I can be finished with this medication, I don't want to try anything else, I Pray 🙏🏽 to God I'm finished with All this medication 🤔🎉🤩 Everyone have a wonderful night 😴

December 1, 2025
A MyMSTeam Member

@A MyMSTeam Member I've been using glatmeir acetate (Copaxone) for over 25 years now. I also did a 5 year period with Betaserone (Avonex) plus Copaxone. I'm pretty much stable as I reach 62. Wish you all the best.

December 1, 2025
MyMSTeam

What can you expect when starting Siponimod (Mayzent) at 62 with borderline SP/PP MS?

Siponimod is approved to treat active secondary progressive MS, relapsing-remitting MS, and clinically isolated syndrome. It works by preventing white blood cells from leaving the lymph nodes and entering the central nervous system, which Show Full Answer

What can you expect when starting Siponimod (Mayzent) at 62 with borderline SP/PP MS?

Siponimod is approved to treat active secondary progressive MS, relapsing-remitting MS, and clinically isolated syndrome. It works by preventing white blood cells from leaving the lymph nodes and entering the central nervous system, which reduces inflammation and helps protect nerve cells from further damage.

In clinical trials, Siponimod showed promising results:
- Reduced the risk of worsening disability in people with SPMS by 21 percent
- Reduced the risk of relapses by 55 percent

Common side effects include headaches, urinary tract infections, falls, and common colds. Your situation sounds similar to experiences shared by other MyMSTeam members. Some have found that MS disease activity can decrease with aging, with fewer new lesions appearing on MRIs over time. A MyMSTeam member shared that their last three MRIs showed no new lesions after years of treatment.

It's encouraging that your EDSS has improved and your recent MRI shows minimal change. This suggests your MS may be relatively stable, though you're still experiencing symptoms like fatigue, bladder issues, and mobility challenges.

Your neurologist can help you understand what to expect with Siponimod based on your specific situation. Many people continue managing symptoms while on disease-modifying therapies, and it's completely normal to have questions about starting a new treatment at this stage.

December 1, 2025
A MyMSTeam Member

God Bless you Josephus.
My prayers go with you 🙏
Best wishes blessings 🙌 joy

December 8, 2025
A MyMSTeam Member

Stay young at heart 💜

December 7, 2025

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