Ampyra (dalfampridine) is actually prescribed specifically to help improve walking in adults with MS — not primarily for fatigue. It's taken as a 10mg tablet twice a day, roughly 12 hours apart. For MS fatigue specifically, there are other medications that doctors sometimes consider, including:
- Modafinil and amantadine — Show Full Answer
Ampyra (dalfampridine) is actually prescribed specifically to help improve walking in adults with MS — not primarily for fatigue. It's taken as a 10mg tablet twice a day, roughly 12 hours apart. For MS fatigue specifically, there are other medications that doctors sometimes consider, including:
- Modafinil and amantadine — shown to help reduce fatigue in some people, though research is still inconclusive
- Antidepressants — may help some people, since depression and fatigue are closely linked in MS
- Stimulants like Adderall — sometimes prescribed off-label, with mixed results
Non-medication strategies can also make a real difference:
- Regular, gentle exercise (think yoga, tai chi, or water-based activities)
- Staying cool and hydrated
- Eating a nutritious diet and avoiding heavily processed foods
- Reviewing current medications with your doctor, as some MS medications can actually contribute to tiredness
It's worth having a full fatigue assessment with your neurologist, since fatigue in MS can be tied to sleep issues, mood, and cognition — all of which may need different approaches.
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