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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 5
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A MyMSTeam Member

Contact your doctor about this it sounds like this is really serious. That kind of mention side effects are those when they did the announcements for Ocrevus Zunovo.

October 5
MyMSTeam

What you're describing sounds like an injection site reaction, which is actually the most common side effect reported with Ocrevus Zunovo. Redness, pain, swelling, and discoloration at the injection site are all well-documented reactions, and most tend to be mild to moderate.

That said, the hardness and bruising you're Show Full Answer

What you're describing sounds like an injection site reaction, which is actually the most common side effect reported with Ocrevus Zunovo. Redness, pain, swelling, and discoloration at the injection site are all well-documented reactions, and most tend to be mild to moderate.

That said, the hardness and bruising you're experiencing, along with how painful it is, is worth mentioning to your doctor or nurse before your next dose. They may be able to adjust how the injection is given or offer additional pretreatment to help reduce the reaction. Here are a few things that may help reduce injection reactions:

- Hydrate well the night before and the morning of your injection — one study found this reduced reactions by 60%
- Take your premedications (antihistamine and corticosteroid) as directed, at least 30 minutes before the injection
- Plan a restful day afterward to give your body time to recover

Most reactions happen within 24 hours of the injection, so knowing what to expect can help. However, if the reaction ever feels severe or gets worse, seek medical attention right away.

October 5

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