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DISEASE-MODIFYING THERAPY
Aubagio (teriflunomide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with multiple sclerosis.
These insights are based on 7,852 comments about Aubagio from MyMSTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Aubagio is a pyrimidine synthesis inhibitor. It blocks an enzyme involved in making pyrimidines, which are building blocks cells need to grow.
The exact way Aubagio works in multiple sclerosis is not known, but it may help by reducing the number of activated immune cells in the central nervous system that cause nerve damage in MS.
Doctors may prescribe Aubagio for adults with a relapsing (returning) form of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, or active secondary progressive disease.
Aubagio is given as a tablet by mouth, typically once each day. It can be taken with or without food.
The recommended dose of Aubagio for multiple sclerosis is 7 milligrams or 14 milligrams by mouth once daily.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 7,852 comments about Aubagio from MyMSTeam members.Members who use Aubagio often say it helps to have realistic expectations, keep up with monitoring, and pay close attention to side effects. Many also mention that routines, timing, and practical support for cost or access can make treatment easier to manage.
Get blood work when your doctor orders it.
“To check for liver health, you have to have a blood test every month for the first six, and I am just about to have my last one.”
Tell your doctor about side effects that do not go away.
“I have been on Aubagio for two months and one week now. I have experienced bowel problems as diarrhea, eczema, and hair loss.”
Talk to your doctor about blood pressure changes.
“My blood pressure has gone from normal, 125 over 71, to 152 over 100. I have contacted my neuro and waiting for an answer.”
Be patient about results, because it may take time.
“I am committed to give it a try for at least six months, after which I will reassess.”
Ask about help if cost or insurance is a problem.
“After filling out paperwork for assistance at the doctor’s office and then later being contacted by an Aubagio rep, they told me not to worry, and all would be taken care of by the Aubagio team.”
Connect with others who understand life with multiple sclerosis. Join MyMSTeam for free.
In clinical trials of Aubagio for relapsing forms of multiple sclerosis in adults, the most common side effects occurred in about 10 percent to 18 percent of people. They include:
Aubagio can cause serious side effects that require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Sanofi, the manufacturer of Aubagio, offers the MS One to One program. To learn more, call 855-676-6326.
Before starting Aubagio, your doctor will test or check for:
Tell your doctor if you have any allergies to teriflunomide or any ingredients in Aubagio. Do not take Aubagio if you have had an allergic reaction to teriflunomide or any ingredients in Aubagio.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Before you take Aubagio, tell your doctor about all of your medical conditions, including if you:
Do not take Aubagio if you have severe liver problems, or if you take leflunomide.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Aubagio, talk with your doctor about the risks and benefits. Do not take Aubagio if you are pregnant.
If you can become pregnant, you should use effective birth control while taking Aubagio and keep using it after stopping until it is confirmed that teriflunomide blood levels are less than 0.02 milligrams per liter.
Men who do not wish to have a child should use effective birth control, and men who want to have a child should stop Aubagio and talk with their doctor about lowering teriflunomide levels before trying to conceive. Women should not breastfeed during treatment with Aubagio.
These answers are fact-checked by our editorial staff.
How effective is Aubagio?
In clinical studies in adults with multiple sclerosis, Aubagio lowered relapse rates compared with placebo (an inactive treatment). In one study, fewer people had disability get worse by week 108 with Aubagio versus placebo (about 20 percent compared with about 27 percent). MRI results also showed fewer active brain lesions with Aubagio.
How long does Aubagio take to work for multiple sclerosis?
It is not known exactly how long Aubagio takes to improve symptoms. The drug builds up in the body over time and reaches steady levels in about three months. In clinical studies, results were measured over two years.
Can Aubagio cause diarrhea or hair loss in people with multiple sclerosis?
Yes. In studies, diarrhea was reported in 13 percent and 14 percent of people taking Aubagio, compared with 8 percent taking placebo. Alopecia (hair loss) was reported in 10 percent and 13 percent of people taking Aubagio, compared with 5 percent taking placebo.
What monitoring is needed with Aubagio for multiple sclerosis?
After starting treatment, your doctor should check your liver with a blood test at least once a month for six months. Your blood pressure should be checked during treatment. Blood counts may be checked if you have signs or symptoms of infection.
On MyMSTeam, people share their experiences with multiple sclerosis, get advice, and find support from others who understand.
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