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Fleqsuvy (baclofen) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat spasticity (muscle stiffness and spasms) resulting from multiple sclerosis in adults and children 12 years of age and older.
These insights are based on 1,507 comments about Fleqsuvy from MyMSTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Fleqsuvy is a muscle relaxant. Its exact way of working is not fully known. It may work like gamma-aminobutyric acid (GABA), a natural chemical in the body that helps control nerve signals.
In people with multiple sclerosis, Fleqsuvy can help relieve spasticity, including muscle spasms and related pain.
Doctors prescribe Fleqsuvy for spasticity (muscle stiffness and spasms) from multiple sclerosis, including flexor spasms and pain, clonus, and muscle rigidity. It can be used in adults and children ages 12 and older.
Fleqsuvy is a liquid medicine taken by mouth. It is taken in multiple doses during the day. Treatment usually starts with a low dose.
The dose is then slowly increased over time.
The recommended starting dose of Fleqsuvy in multiple sclerosis is 1 milliliter (5 milligrams) three times a day for three days.
For people who respond to treatment, the maximum maintenance dose is 4 milliliters (20 milligrams) four times a day.
Doctors may increase the dose slowly based on how the person responds and how well they tolerate it. They will also reduce the dose slowly when stopping treatment rather than stopping it suddenly.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 1,507 comments about Fleqsuvy from MyMSTeam members.Members who use Fleqsuvy often say it can help with spasticity, but finding the right routine may take time. Across the community, members most often suggest paying close attention to side effects, working with a doctor on dose changes, staying consistent with timing, and adding physical therapy, stretching, or exercise when possible.
Watch for sleepiness, dizziness, or weakness.
“I was on Baclofen, but with the higher the dose, the dizzier and sleepier I became.”
Talk to your doctor about dose changes.
“Have you spoken with your neurologist about increasing the dose of Baclofen? 10 milligrams may be too low.”
Do not stop Fleqsuvy suddenly.
“I stopped taking Baclofen some years back, and in two days I was going through withdrawals and the spasms got real intense.”
Keep a regular routine with your doses.
“In the mornings my muscles are tight, so I have to do a little stretching. But I commute to work so I take my baclofen before I leave and head off to work.”
Add stretching, physical therapy, or exercise if you can.
“Walking issues and spasms for me got better with baclofen and a lot of physiotherapy. It takes some time to make a difference but stay persistent!”
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The most common side effect was drowsiness, which occurred in up to 63 percent of people. Other common side effects reported in up to 15 percent of people were:
Fleqsuvy can cause serious side effects that require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Azurity Pharmaceuticals, the manufacturer of Fleqsuvy, offers the Azurity Solutions Patient Support Program. Eligible people with commercial insurance may qualify for copay savings for certain medications. At this time, the program does not appear to list a Fleqsuvy-specific copay or savings offer.
Azurity Solutions also helps connect people with independent pharmacies that may offer lower out-of-pocket costs and home delivery services through its enrollment-based support program. To learn more, visit Azurity Solutions or call 800-461-7449.
Tell your doctor if you have any allergies to baclofen or any ingredients in Fleqsuvy. Do not take Fleqsuvy if you have had a serious allergic reaction to baclofen or any of its ingredients.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Before taking Fleqsuvy, tell your healthcare provider if you:
Fleqsuvy can cause drowsiness. This effect can be stronger if it is taken with alcohol or other medicines that slow down the brain, such as certain sedatives.
Do not discontinue Fleqsuvy without consulting your healthcare provider. Sudden withdrawal of Fleqsuvy can result in serious complications.
Do not drive or operate heavy machinery after taking your dose of Fleqsuvy until you know how it affects you.
Fleqsuvy may also be of some value in people with spinal cord injuries and other spinal cord diseases.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Fleqsuvy, talk with your doctor about the risks and benefits. Withdrawal symptoms in babies whose mothers were treated with oral baclofen throughout pregnancy have been reported. Baclofen is present in human breast milk.
Withdrawal symptoms can occur in breastfed babies when mothers stop taking Fleqsuvy or when breastfeeding is stopped. You and your healthcare provider will decide if you should take Fleqsuvy while you are pregnant or breastfeeding.
These answers are fact-checked by our editorial staff.
How effective is Fleqsuvy?
Fleqsuvy is used to treat spasticity caused by multiple sclerosis. It can help reduce muscle spasms, pain, shaking, and tight (rigid) muscles. Fleqsuvy contains baclofen, a medicine that has been used for many years to treat spasticity.
It works by calming the signals in the spinal cord that make muscles tighten. Because baclofen has been used for many years, doctors already understand how it helps relax muscles.
In studies, Fleqsuvy liquid was shown to deliver similar amounts of baclofen into the body as baclofen tablets. This means it is expected to work the same way. In one study, the highest level of the medicine in the blood was reached about one hour after taking it on an empty stomach.
What tests or monitoring are needed with Fleqsuvy?
Fleqsuvy does not usually require regular lab tests. Doctors monitor how well it works and watch for side effects. They check for things like sleepiness, dizziness, and muscle weakness.
The dose may be adjusted based on how the person responds. When stopping the medicine, the dose should be lowered slowly while being monitored.
How long does Fleqsuvy take to work for spasticity in multiple sclerosis?
It is not known exactly how long Fleqsuvy takes to work. The dose is usually started low and increased slowly over time. This means it may take time to see the full effect.
Some people may notice improvement as the dose is adjusted based on their response.
Can Fleqsuvy cause drowsiness for people with multiple sclerosis?
Yes. Drowsiness is the most common adverse reaction with Fleqsuvy, and in one controlled study it was reported in 63 percent of people taking Fleqsuvy compared with 36 percent taking placebo (an inactive treatment). People should avoid driving or other hazardous activities when starting treatment or increasing the dose until they know how it affects them.
On MyMSTeam, people share their experiences with multiple sclerosis, get advice, and find support from others who understand.
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