Nuedexta (Dextromethorphan/Quinidine) for Multiple Sclerosis | MyMSTeam

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Nuedexta is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pseudobulbar affect, or PBA (episodes of involuntary laughter or crying) in people with multiple sclerosis (MS) and other neurological diseases. Nuedexta is a combination drug composed of dextromethorphan and quinidine.

Dextromethorphan is a drug of the morphinan class, and a common ingredient in cough suppressants. Dextromethorphan is believed to work in cases of PBA by regulating excitatory neurotransmissions responsible for involuntary laughing and crying. Quinidine, a drug related to quinine, is used to treat arrhythmia (irregular heartbeat). Quinidine is believed to work in cases of PBA by making dextromethorphan more available in the body.

How do I take it?
Nuedexta is taken orally as prescribed by a doctor.

Nuedexta comes in capsule form.

Side effects
The FDA-approved label for Nuedexta lists common side effects including dizziness, cough, flu symptoms, weakness, swelling in the extremities, diarrhea, vomiting, flatulence, and urinary tract infection.

Rare but serious side effects listed for Nuedexta include blood cell disorders, hepatitis, changes in heart rhythm, problems with the left ventricle of the heart, and serotonin syndrome.

For more details about this treatment, visit:

Nuedexta — Avanir

Nuedexta — National MS Society

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