I use to take Aleve before my Rebif shots too. It helps a lot!! I'm no longer on Rebif but I still take Aleve and it's all I'll take for any pain. Over the counter wise that it. I also have the Fentanyl patch as a pain medication. But that's an rx.

I take aleive before I take my Rebif shot and then I dont get headaches from it other than that I have norco for my really bad days.

Thank you all I have been using aleve as well and my Nuero prescribed me something called Indomethacin for my head pain. Crawling under a rock sounds great at the moment though!

Nothing works all the time. Normally I take Advil before my Rebif injection. But when I have a BAD headache, I may start out with Advil, then have to take XS Excedrin (sp?), and finally Aleve (about 3-4 hours apart). If that doesn't work, I crawl inside a hole or under a rock.