Yes, my doctor said there is not always a correlation nap between lesions and progression of symptoms. I always thought they went together.

Mee too. I have gradually progressed in symptoms over past couple years. I can look back a few months and wish I had some of THOSE abilities back. I have had pseudo exhaserbations but nothing SERIOUSLY scary and MRIs show very little change. Doc mentioned at my appt a week ago that I may be secondary prog but he " had to think on it" cuz I haven't been diagnosed for 10 years. That is annoying to because first, I had serious issue and saw ms years before documented Dx (as seen on old MRIs by a new doc). So just because I didn't have it on paper doesn't mean it wasn't wrong in beginning. Second, don't put me by your book if you also say it is different for everyone.

I see my disease change a lot no matter my MRIs showing only minimal change.

I also have a stable MRI and never any enhancing lesions. However my disability has continued. I have had several "pseudo" exacerbation due to stress and fatigue that have ended me in the hospital for steroid treatment. I asked my neuro if I had progressed to secondary and he asked me if I was progressing and I said yes so he agreed. Not sure if that was really an answer. I can measure my progression by looking at what I could do last year that I can't do this year.

I too have had progression without getting new lesions. My Neuro told me that MS is always working regardless of lesions.

I definately feel my fatigue and cognition are worse, and my MRI is stable. Who knows why???