Rebif is an injection 3 times a week, Tec is 1 pill twice a day. Both slow the progression of MS, the pills seem to have less side effects listed. I was on Rebif for many years and it was very helpful. But psychologically, it was very hard to give myself a shot. It really boils down to if you'd rather take the shot or pill. I will start Tec this week.

I just switched from REBIF to Tecfidera, 2 months ago. The shots sucked but they're not horrible. I've bee feeling worse since Tecfidera, Don't know if it will get better...

I take Techfludera. I'm a male, though, who has two healthy children. So I don't have the "want more children. Clock ticking!" thing happening to me. My wife had her tubes tied after second one so we're all done with babies. I'm 42, she's 41. Good luck with your decision!

Been on rebif for 7 years and in the process of switching to tecfidera just 'cause I'm sick of doing shots. Was on copaxone for 6 years before rebif. Both worked great-rebif probably a little better. Even after 7 yrs of rebif, I STILL get the mega headache! Think you would have to stop either one before getting pregnant. Good luck!

I took Rebif for more than a year. Sometimes I had no side effects and others times I would get horrible headaches. I am 5,7 and was 140 lbs before rebif. My weight dropped to 108 lbs. I joined a clinical trial in Tucson. No placebo and was drawn for alemetuzumab. Treatments 3 over 3 years were hard but much better than injections. I opted for the trial because my liver enzymes increased so much I only had a few months left on rebif. My husband said after I stopped that he could see the injections killing me. I was 28