My neurologist says it's a symptom lasting 3 days or more! So if I'm having a new symptom I call if it's lasted for 3 days. Hope this helps:)

I am not sure but I know I have been down hill till lately. The Ampyra has helped my legs. The amantadine has helped my fatigue. I drink one or two cups of coffee in the morning then water the rest of the day. I know eating healthy (low fat, sugar) helps.
When I first got sick I was offered two meds for fatigue, Amantadine and ridlan. I chose amantadine and it is weak but just enough to keep me awake.

Thank you

I have the same question, yesterday I did not have a good day, but it really wasn't different from any other day. Today I am really sleepy, I know that I could go lay down for a couple of hours and not feel any better, except while I am sleeping of course. I am not sure if this is a real exacerbation or not.Could someone help me answer that question.

I lived in Bellingham in the 70s as a boy. It rained every day!