I experienced severe stomach pain and nausea along with flushing skin. With a few diet adjustments I no longer have any side effects.
1 eat some applesauce right before taking Tecfidera. This works great to prevent flushing.

2 The stomach pain is caused by inflamation of the stomach lining. Take a good heatburn medication daily.

3 fatty foods that coat the stomach work really well. I eat a couple tablespoons of peant butter before every dose.
These 3 things made my very uncomfortable side effects completely disappear.

@A MyMSTeam Member...I've also had people recommend taking a fish oil supplement when taking the pill to help coat the stomach plus it's good for you. I too had some really severe stomach pain but after quitting and starting over with a lower dose and ramping up slowly my side effects are basically gone. I do find what I eat definitely influences stomach issues.

Mentioned Users

A MyMSTea...

I am new to Tec. Just started the lower dose 5 days ago. No flushing but minor manageable stomach issues. I start the highest dose in 3 days....things could change but so far the side affects are mild.

I was on Tecfidara for about 3 weeks. The nausea and diarrhea settled down a little bit but the hot flashes, flushing and the random rashes were more than I could take.

Tecfidera was the first Medication I tried after my Diagnosis. I think the only side effect I had was some stomach issues but that went away after the first week, I switched to Ocrevus about 6 years ago and its been working great.