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A MyMSTeam Member asked a question 💭
East Moline, IL

My question is has anyone on here ever been "diagnosed" with M.S with a negative MRI or CSF tap?

August 10, 2021
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A MyMSTeam Member

Yes you can have multiple sclerosis with any lesion spots just have the symptoms

August 11, 2021
A MyMSTeam Member

Without That’s what my neurologist told me

August 11, 2021
A MyMSTeam Member

I have positive MRI of head, negative spinal tap.

August 11, 2021
A MyMSTeam Member

Yes . . my CSF did not confirm it. I don't think it was negative, but the number of bands (I am not clear on the name or what they are counting) were lower than what would be the amount to confirm MS. But after many tests and ruling out many other conditions, several Neurologists and specialists, my Neurologist did confirm and conclude that my diagnosis is MS. She said mine was more unique (?) not good for me really because most of the common meds do not work for me. I wonder if that has something to do with it, who knows. I have seen some other people say this also, that the CSF did not confirm MS. I guess it happens once in a while . .

August 10, 2021
MyMSTeam

Certainly! Here are the methods used to diagnose multiple sclerosis (MS) based on the knowledge base:

Diagnostic Criteria
- McDonald Criteria
- Evidence of damage in at least two separate parts of the central nervous system (CNS), which includes the brain, spinal cord, and optic nerves.
- Evidence that the CNS Show Full Answer

Certainly! Here are the methods used to diagnose multiple sclerosis (MS) based on the knowledge base:

Diagnostic Criteria
- McDonald Criteria:
- Evidence of damage in at least two separate parts of the central nervous system (CNS), which includes the brain, spinal cord, and optic nerves.
- Evidence that the CNS damage happened at different times.
- Every other possible condition has been ruled out.

Diagnostic Tests
- Medical History:
- Symptoms over time.
- Family medical history.
- Birthplace.
- Possible exposures to toxins or infections.

- Neurological Examination:
- Examining eyes and reflexes for signs of nerve damage.
- Testing for weakness or lack of coordination.
- Testing for loss of sensation using a vibrating tuning fork, or sharp or dull items.

- Magnetic Resonance Imaging (MRI):
- Uses a strong magnetic field and radio waves to measure the relative water content in tissues.
- Helps in identifying lesions in the brain and spinal cord.

- Evoked Potential (EP) Tests:
- Somatosensory EP test involves minor, painless shocks to arms and legs to measure electrical activity in the brain.

- Lumbar Puncture (Spinal Tap):
- Analyzes cerebrospinal fluid (CSF) for abnormalities.

- Blood Tests:
- Used to rule out other conditions that might mimic MS symptoms.

Types of MS Diagnosed
- Clinically Isolated Syndrome (CIS):
- Symptoms of MS with damage visible in only one area of the CNS.
- Regular checks for new lesions and possible treatment with disease-modifying therapy.

- Relapsing-Remitting MS (RRMS):
- About 85% of individuals diagnosed with MS initially have this type.

- Primary Progressive MS (PPMS):
- The remaining 15% of individuals diagnosed with MS have this type.

Additional Information
- CT Scans:
- Uses radiation to take images of brain tissue, sometimes with a contrast solution to highlight structures.

- Other Conditions:
- Ruling out other conditions is crucial to prevent misdiagnosis.

For more detailed information, you can refer to the resources provided in the knowledge base, such as the Cleveland Clinic, National Multiple Sclerosis Society, and Mayo Clinic.

July 25, 2024

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