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A MyMSTeam Member asked a question 💭
Rockhampton, AU

Hi,
I am currently on Ocrevus and have had covid. It's been a month since covid and I am struggling to get my health back on track. I am contemplating swapping to Mavenclad, has anyone done this?

January 16, 2023
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MyMSTeam

Ocrevus (Ocrelizumab)
- Approval: Approved by the FDA to treat both relapsing and primary progressive forms of multiple sclerosis
- Mechanism: Biologic immunomodulator that reduces the number of CD20-positive B cells, which are involved in nerve cell attacks
- Administration: Intravenous infusion once every six months Show Full Answer

Ocrevus (Ocrelizumab)
- Approval: Approved by the FDA to treat both relapsing and primary progressive forms of multiple sclerosis.
- Mechanism: Biologic immunomodulator that reduces the number of CD20-positive B cells, which are involved in nerve cell attacks.
- Administration: Intravenous infusion once every six months after initial loading doses.
- Common Side Effects:
- Infusion reactions (headache, dizziness, fever, nausea, itching, rash, flushed skin, low blood pressure, fast heartbeat)
- Infections of the skin and respiratory tract
- Serious Side Effects:
- Severe infusion reactions
- Increased risk for some types of cancer

Mavenclad (Cladribine)
- Approval: Approved by the FDA to treat adults with relapsing forms of multiple sclerosis, including relapsing-remitting MS and active secondary progressive MS. Typically prescribed when other treatments are ineffective or poorly tolerated.
- Mechanism: Immunomodulator that reduces the number of B and T lymphocytes, which contribute to autoimmune attacks in MS.
- Administration: Oral tablets taken during two separate treatment courses each year, with each course lasting two weeks and about a month between courses.
- Common Side Effects:
- Headache
- Low white blood cell count
- Upper respiratory tract infection
- Serious Side Effects:
- Increased risk for low blood cell counts
- Serious infections
- Blood disorders
- Liver toxicity or injury
- Risk of developing graft-versus-host disease (GVHD) after receiving blood transfusions

For more details, you can visit the respective pages:
- [Ocrevus](https://www.mymsteam.com/treatments/ocrevus)
- [Mavenclad](https://www.mymsteam.com/treatments/mavenclad)

July 9, 2024
A MyMSTeam Member

Ocrevus was fine, it's takes some time having it administered. 1 hr post meds - antihistamines, paracetamol. Then it's about 5 hours to run the Ocrevus through the drip. It's only twice a year. So, it doesn't impact on your lifestyle. It's a great time to sit and chill, be waited on and not have to think about anything.

January 19, 2023
A MyMSTeam Member

How did you manage on ocrevus, any side effects, I have just been offered it, I have ppms,

January 19, 2023
A MyMSTeam Member

Having ms makes it harder for your body to recover from COVID. We already have a compromised immune system. Recovery will be slower. If I were you I would wait to change medications until you have recovered from COVID. It may take much longer, but if it worked before you got COVID then you may want to wait a while before you change. Sorry you have to deal with this. ☺️

January 16, 2023

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