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It depends where the lesions are. The spinal tap just checks for spine lesions/damage in spinal cord. I have brain lesions and my spinal tap was negative. A year later I had a spine lesion form and was fully diagnosed. Here they need to check a bunch of boxes before you can be fully diagnosed for legal reasons.
I had confirmed MS with a negative spinal tap
I was diagnosed without having a spinal tap so I'm not sure what mine would show.
Yes, it is possible to have multiple sclerosis (MS) even if your spinal fluid does not show abnormalities. While cerebrospinal fluid (CSF) analysis can help in diagnosing MS by showing elevated levels of certain proteins and antibodies, about 5 to 10 percent of people with a confirmed MS diagnosis do not show any Show Full Answer
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