Can Ocrevus treat secondary progressive MS?
Ocrevus (ocrelizumab) is not specifically approved for secondary progressive MS (SPMS). It's approved for relapsing forms of MS and primary progressive MS.
However, if you have active SPMS — meaning you're still experiencing relapses — Ocrevus might be an option since it treats Show Full Answer
Can Ocrevus treat secondary progressive MS?
Ocrevus (ocrelizumab) is not specifically approved for secondary progressive MS (SPMS). It's approved for relapsing forms of MS and primary progressive MS.
However, if you have active SPMS — meaning you're still experiencing relapses — Ocrevus might be an option since it treats relapsing forms of the disease.
For SPMS specifically, other medications have FDA approval, including:
- Mayzent (siponimod)
- Zeposia (ozanimod)
- Mavenclad (cladribine)
- Rebif (interferon beta-1a)
- Copaxone (glatiramer acetate)
- Novantrone (mitoxantrone)
Your neurologist can help determine the best treatment based on whether your SPMS is active (with relapses) or non-active, and discuss potential side effects for each option.
November 5, 2025