I use large doses of both for spasticity.
I used it but it didn't work, also used baclofen but it made the spasticity worse. I now take Robaxin 750mg 3 times a day which works wonders.
I started on Tizanidine but found I am allergic to it
@A MyMSTeam Member Robaxin just happened to be the next one in line I guess so we tried it. I haven't had any side effects from it, just relief from the spasticity.
Tizzy made me dizzy! Baclofen did not. It's up to you and how each feels imho.