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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMSTeam Member asked a question 💭
Tucson, AZ
December 28, 2025
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A MyMSTeam Member

Now that is a question for your doctor. I'm not sure if it would be safe?

December 29, 2025 (edited)
MyMSTeam

Can you take GLP-1 medications with MS if you're not overweight?

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) are currently approved as weight-loss drugs specifically for people with a BMI in the overweight or obese range, under certain circumstances. They were originally developed to treat type 2 diabetes.

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Can you take GLP-1 medications with MS if you're not overweight?

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) are currently approved as weight-loss drugs specifically for people with a BMI in the overweight or obese range, under certain circumstances. They were originally developed to treat type 2 diabetes.

If weight loss isn't a goal for you, these medications may not be appropriate. The research and approval for GLP-1 agonists in MS focuses on people who need to lose weight, as higher body weight can worsen MS symptoms like pain and bladder problems.

That said, researchers are exploring whether GLP-1 agonists might help people with MS rebuild damaged myelin or slow demyelination. However, these ideas are in very early stages with no clinical trials yet, so much more research is needed.

If you're interested in GLP-1 medications for any reason, it's essential to discuss this with your doctor. They can help determine if there's a medical reason that would make these drugs appropriate for your specific situation, considering your MS and overall health needs.

December 28, 2025
A MyMSTeam Member

Adults with Type 2 diabetes, especially when other meds aren't enough.
People with Type 2 diabetes and obesity.
Those with cardiovascular risk factors (heart disease, stroke).

December 28, 2025

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