Yes, there is a relationship, but it is complex and not simply “MS causes low cortisol.” Research shows the hypothalamic-pituitary-adrenal (HPA) axis is often dysregulated in multiple sclerosis (MS), leading to altered cortisol levels that can be higher or lower depending on the context, stage, and symptoms. 
August 1
Great question! Cortisol is a natural steroid hormone your body produces in response to stress, and it plays a key role in controlling inflammation, metabolism, and cognition. Since MS is an inflammatory condition, cortisol is very relevant here.
The body's natural cortisol helps keep inflammation in check. When cortisol Show Full Answer
Great question! Cortisol is a natural steroid hormone your body produces in response to stress, and it plays a key role in controlling inflammation, metabolism, and cognition. Since MS is an inflammatory condition, cortisol is very relevant here.
The body's natural cortisol helps keep inflammation in check. When cortisol levels are low, the body may struggle to regulate inflammation effectively, which could potentially worsen MS symptoms or contribute to relapses. This is actually why doctors sometimes prescribe lab-made versions of cortisol, called corticosteroids (like methylprednisolone), to help manage MS relapses. These medications mimic what cortisol does naturally — reducing inflammation during flare-ups.
A few important things to keep in mind:
- Corticosteroids are typically prescribed for short courses of 3–5 days during relapses
- They can help with severe symptoms like mobility and vision problems
- They do come with potential side effects, so they aren't used long-term
It's always worth discussing your cortisol levels and any concerns with your neurologist, as they can assess whether hormonal factors may be influencing your MS symptoms.
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diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.
Hormones and MS: 8 Facts To Know
August 1