MyMSTeam

Thank you for sharing this — this is genuinely important information for anyone with MS who is on a B-cell depleting therapy like Ocrevus (ocrelizumab), Kesimpta (ofatumumab), Briumvi (ublituximab), or rituximab.

Here's what makes this particularly relevant: B-cell depleting therapies work by reducing certain immune cells Show Full Answer

Thank you for sharing this — this is genuinely important information for anyone with MS who is on a B-cell depleting therapy like Ocrevus (ocrelizumab), Kesimpta (ofatumumab), Briumvi (ublituximab), or rituximab.

Here's what makes this particularly relevant: B-cell depleting therapies work by reducing certain immune cells in your body. While this is great for controlling MS, it also means your body may struggle to produce antibodies against a new infection — including mosquito- or tick-borne viruses. What the CDC advisory means for you practically:

- Prevent bites — Use EPA-registered insect repellent, wear long sleeves and pants outdoors, and avoid peak mosquito hours (dusk and dawn)
- Tell your doctor you're on a B-cell depleting therapy if you develop symptoms like fever, headache, confusion, or neurological changes after possible mosquito or tick exposure
- Ask specifically for PCR/molecular testing — standard antibody-based tests may give false negatives because your body may not be producing antibodies normally while on these medications
- Don't wait — if symptoms appear, seek medical attention promptly

This is not a reason to stop your MS treatment, but it is a very good reason to be proactive about bite prevention and to make sure your care team is informed.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

B-Cell Depletion Therapy in Multiple Sclerosis Explained