Is There a Cure for MS? Dr. Boster on Recent Research Advances (VIDEO) | MyMSTeam

Connect with others who understand.

sign up Log in
Resources
About MyMSTeam
Powered By

Is There a Cure for MS? Dr. Boster on Recent Research Advances (VIDEO)

Updated on January 22, 2024

  • There’s not yet a cure for multiple sclerosis (MS) in the foreseeable future, but the chronic illness is more treatable than ever before.
  • Research is focused on finding ways to repair nerve damage caused by MS and protect against brain atrophy.
  • There are four actions you can take now to improve your quality of life with MS until a cure is found.

Will we ever see a cure for multiple sclerosis? That’s one of the most frequently asked questions — and topics of conversation — among people living with this disease. “I’m so tired of feeling this way every day,” said one member of MyMSTeam. “I wish MS had a cure.” Another commented, “Praying that a cure for this disability is found in my lifetime!”

    Although researchers have more insights into possible causes of MS, we’re still a long way off from a cure, according to Dr. Aaron Boster. A board-certified neurologist and president of The Boster Center for Multiple Sclerosis in Columbus, Ohio, Dr. Boster also has a YouTube channel covering many aspects of treating and living with MS.

    “It’s unlikely that we're going to find a cure in my lifetime,” Dr. Boster explained in an exclusive interview with MyMSTeam. “I’m not saying that to be Debbie Downer. It’s still largely uncharted territory.”

    The good news: Scientists are honing in on ways to improve quality of life with MS, which affects nearly 1 million people in the U.S. More MS therapies are being developed than ever before, according to the National Multiple Sclerosis Society. The disease is also being diagnosed earlier, so disease-modifying treatments can begin sooner. And scientists are discovering possible risk factors that could eventually help prevent the disease.

    Thanks to these advances, MS will eventually become a “boring” chronic disease, Dr. Boster predicted. Like diabetes, MS would be managed with diet, lifestyle modifications, and medications.

    “We’re starting to get successful at making MS boring,” he said. “That’s a realistic goal for everyone with the condition.”

    Closer to a Cure: Breakthrough Therapies for MS

    MS is thought to occur when the body’s immune system attacks the central nervous system (CNS), causing inflammation that damages the myelin sheath, a protective coating around nerves of the brain and spinal cord. This neurological (nerve) damage disrupts the signals those nerves send to other parts of the body, causing common MS symptoms such as difficulty walking, spasticity, muscle weakness, fatigue, and cognitive fog.


    In clinical trials, DMTs have been shown to help reduce the frequency and severity of MS flare-ups.

    Enter Cell 2 Content Here...

    Enter Cell 3 Content Here...

    Enter Cell 4 Content Here...

    Enter Cell 5 Content Here...

    Enter Cell 6 Content Here...


    Health experts believe that stopping inflammation is the key to stopping the disease in its tracks. In his interview with MyMSTeam, Dr. Boster identified three treatment types under development that are important steps toward improved quality of life — and possibly a cure. These are disease-modifying therapies (DMTs), remyelination treatment, and neuroprotective therapies.

    Disease-Modifying Therapies

    DMTs work by modifying immune system activity to slow the course of active MS. Although these drugs can’t cure MS, they’ve been highly effective at reducing the inflammation that causes nerve damage and slowing disease progression.

    There are more than 25 DMTs approved by the U.S. Food and Drug Administration (FDA), which can be administered orally or by injection or infusion. In clinical trials, DMTs have been shown to help reduce the frequency and severity of flare-ups. They can also reduce the development of new lesions and slow disability. New DMTs continue to be developed for more effective treatment of MS.

    DMTs are prescribed primarily for people with relapsing forms of MS, which include relapsing-remitting MS (RRMS), clinically isolated syndrome (CIS), and active secondary-progressive MS (SPMS). They include drugs in several different classes that work in different ways.

    Here are some classes of DMTs along with examples:

    • Injected interferons such as interferon beta-1a (Avonex), interferon beta-1b (Betaseron), and peginterferon beta-1a (Plegridy)
    • Oral sphingosine-1-phosphate (S1P) receptor modulators such as fingolimod (Gilenya), siponimod (Mayzent), and ozanimod (Zeposia)
    • Oral fumarates including dimethyl fumarate (Tecfidera) and diroximel fumarate (Vumerity)
    • Injected monoclonal antibodies, also known as biologics, such as natalizumab (Tysabri), alemtuzumab (Lemtrada), and ocrelizumab (Ocrevus)
    • Glatiramer acetate (Copaxone), which is also injected
    • Cladribine (Mavenclad), an oral medication

    In addition to treating relapsing MS, Ocrevus was the first and is currently the only DMT indicated by FDA to treat primary progressive MS (PPMS).

    Although DMTs are the best defense against MS to date, each person responds differently to the medications, and the drugs can have significant side effects. Your neurologist can recommend the best treatment options for your type and stage of MS. In partnership with your neurologist, you’ll make decisions about when to start, stop, or switch MS medications.


    “We’re probably a few years out from having remyelinating agents available. That’s a short period of time.”
    — Dr. Aaron Boster

    Enter Cell 2 Content Here...

    Enter Cell 3 Content Here...

    Enter Cell 4 Content Here...

    Enter Cell 5 Content Here...

    Enter Cell 6 Content Here...


    Remyelination Treatment

    Although DMTs can reduce inflammation that damages nerves, they can’t stop or repair damage that has already occurred. Remyelination treatment, on the other hand, has the potential to transform MS from a disabling disorder to a manageable one.

    “We’re probably a few years out from having remyelinating agents available. That’s a short period of time,” said Dr. Boster, who shared that he has taken part in several “really exciting” trials.

    According to one group of researchers, treatments aimed at remyelination are likely to become available within the next decade. Scientists are currently studying ways to stimulate the brain’s natural ability to repair damaged nerves in a person with MS.

    A few of the compounds currently being studied for remyelination include:

    • S1P receptor modulators, some of which are already approved as DMTs
    • Clemastine fumarate, an antihistamine (anti-allergy drug)
    • Sex hormones such as testosterone

    Results from these and other clinical studies will hopefully make it clear which remyelination strategies are most likely to be safe and effective for people with MS.

    Neuroprotective Therapies

    Researchers are also investigating therapies that could slow brain atrophy, one of the most destructive actions of progressive MS and a reliable predictor of future physical and cognitive disability.

    “We know that people impacted by MS have accelerated shrinkage of the brain and lose their functional reserve,” said Dr. Boster. “We need something to protect against that.”

    Unfortunately, he added, a neuroprotective agent doesn’t yet exist

    A few examples of medications being studied for their potential neuroprotective abilities include:

    • Bruton’s tyrosine kinase (BTK) inhibitors such as evobrutinib
    • Phosphodiesterase (PDE) inhibitors such as ibudilast
    • Minocycline, a tetracycline antibiotic
    • Forms of coenzyme Q10 such as mitoquinone

    If studies can show that one or more drugs can safely prevent the worsening of brain atrophy in MS, new treatments focused on neuroprotection may be forthcoming.


    “We know that people impacted by MS have accelerated shrinkage of the brain and lose their functional reserve. We need something to protect against that.”
    — Dr. Aaron Boster

    Enter Cell 2 Content Here...

    Enter Cell 3 Content Here...

    Enter Cell 4 Content Here...

    Enter Cell 5 Content Here...

    Enter Cell 6 Content Here...


    Other Emerging Treatments

    Ongoing research in the treatment of MS continues to expand and more experimental therapies are emerging. Breakthroughs in gene research are identifying genetic variants and genetic biomarkers associated with disease activity in people with MS. Genetic biomarkers, also known as genetic markers, can help identify who is susceptible to disease. Genetic research is one avenue that may lead to new types of treatment for MS.

    Dr. Boster’s Four Strategies for Managing MS

    Until a cure is discovered, Dr. Boster says the best defense against MS is fourfold. He recommends the following strategies for improving your quality of life with MS.

    1. Find the Best DMT for You

    Deciding on an MS treatment requires a careful discussion with your neurologist to determine which medication is right for you. “I want [my patients] to take the most effective DMT they’re comfortable with,” Dr. Boster explained. “I also want to make sure it’s working for them.”

    2. Get Moving

    Aside from promoting good health in general, physical activity can help manage many MS symptoms. “Exercise should be part of your lifestyle,” Dr. Boster said.

    3. Follow the Two Ds

    Vitamin D and diet are essential to good MS defense, according to Dr. Boster. Low levels of vitamin D are common in people with MS. You can ask your doctor to check your vitamin D levels with a blood test. If you have low levels of the vitamin, Dr. Boster recommends discussing supplementation with your physician.

    Diet is another important MS defense. A nutritious, well-balanced diet has the potential to reduce symptoms and improve quality of life. The National Multiple Sclerosis Society recommends the following:

    • Prepare meals at home as often as possible,
    • Eat colorful fresh fruits and vegetables daily.
    • Opt for whole grains over refined grains.
    • Avoid or limit how much processed food and added sugar you consume.

    Try these ideas for healthy snacks and quick bites.

    4. Kick Butts

    Smoking has been shown to promote disease activity and increase the severity of symptoms, cognitive impairment, and disability progression. It may also inhibit the benefits of DMTs. It’s very important to avoid tobacco, Dr. Boster warned.

    Talk With Others Who Understand

    MyMSTeam is the social network for people with multiple sclerosis and their loved ones. On MyMSTeam, more than 206,000 members come together to ask questions, give advice, and share their stories with others who understand life with MS.

    Do you follow news about MS research and the search for a cure? What works for you to manage your MS until a cure becomes available? Share with others in the comments below or by starting a new conversation on MyMSTeam.

      Updated on January 22, 2024
      All updates must be accompanied by text or a picture.

      Become a Subscriber

      Get the latest articles about multiple sclerosis sent to your inbox.

      This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
      Kiran Chaudhari, M.B.B.S., M.D., Ph.D. is a specialist in pharmacology and neuroscience and is passionate about drug and device safety and pharmacovigilance. Learn more about him here
      Kelly Crumrin is a senior editor at MyHealthTeam and leads the creation of content that educates and empowers people with chronic illnesses. Learn more about her here
      Laurie Berger has been a health care writer, reporter, and editor for the past 14 years. Learn more about her here

      Related Articles

      If you have multiple sclerosis (MS) and want to switch treatments, you may need to wait for one d...

      MS DMTs and Washout Periods: 8 Facts To Know

      If you have multiple sclerosis (MS) and want to switch treatments, you may need to wait for one d...
      Samantha Salvaggio Vanderman is a chronic illness coach, personal trainer, and behavior change s...

      Overcome MS: 4 Tips for Choosing a Treatment

      Samantha Salvaggio Vanderman is a chronic illness coach, personal trainer, and behavior change s...
      As we learn more about multiple sclerosis (MS), researchers continue to look for new treatment op...

      How Are New MS Medications Approved by the FDA? 6 Steps

      As we learn more about multiple sclerosis (MS), researchers continue to look for new treatment op...
      Nearly 30 years ago, the U.S. Food and Drug Administration (FDA) approved the first disease-modif...

      Top 5 Medications Used by MyMSTeam Members

      Nearly 30 years ago, the U.S. Food and Drug Administration (FDA) approved the first disease-modif...
      Multiple sclerosis (MS) can result in a wide variety of symptoms. In some people, that may includ...

      Antiepileptic Drugs for MS Symptoms: How Are They Used?

      Multiple sclerosis (MS) can result in a wide variety of symptoms. In some people, that may includ...
      If you’re living with multiple sclerosis (MS), you may have heard that compression socks (also c...

      3 Ways Compression Socks May Help With MS Symptoms

      If you’re living with multiple sclerosis (MS), you may have heard that compression socks (also c...

      Recent Articles

      Your race or ethnicity can influence many aspects of your life, including how you’re affected by ...

      MS Prevalence by Race and Ethnicity: In the Black Community and More

      Your race or ethnicity can influence many aspects of your life, including how you’re affected by ...
      Relapsing multiple sclerosis (MS) is an unpredictable disease, and most people living with it sw...

      How To Switch MS Treatments

      Relapsing multiple sclerosis (MS) is an unpredictable disease, and most people living with it sw...
      Diphenhydramine — sold under many brand names including Benadryl — is a type of antihistamine tha...

      Why Is Benadryl Given With Some MS Treatments?

      Diphenhydramine — sold under many brand names including Benadryl — is a type of antihistamine tha...
      When multiple sclerosis (MS) symptoms intensify, worsening anxiety and discomfort can make it har...

      Emergencies and Hospital Stays for MS Relapse: When To Go and What It Means for Treatment

      When multiple sclerosis (MS) symptoms intensify, worsening anxiety and discomfort can make it har...
      Read on to find out possible causes of neck, jaw, or collarbone pain, and how others with MS have...

      MS and Pain in the Collarbone, Neck, and Jaw

      Read on to find out possible causes of neck, jaw, or collarbone pain, and how others with MS have...
      Explore how others with multiple sclerosis experience shoulder pain and what they recommend to tr...

      Shoulder Pain and MS: Members Describe Symptoms and Share Tips

      Explore how others with multiple sclerosis experience shoulder pain and what they recommend to tr...
      MyMSTeam My multiple sclerosis Team

      Thank you for subscribing!

      Become a member to get even more:

      sign up for free

      close