I've had some luck with Neurontin. My neuro prescribed it for the nightly leg spasms & chronic headaches. Both have greatly diminished since! Stress really triggers the leg spasms.

Have you tried a muscle relaxant before bed? Or a seizure med like keppra that's what they've tried me on cause mine was soo bad it kept me awake n paranoid n so far it's helped

My neuro wanted me to try the drug thing before blaming the MS, so we'll see.

I've been taking baclofen at night for years so I don't thin it is helping. I'm trying to go off of some of the drugs I'm on to see if that is the problem, one at a time.

I take baclofen at night to control my leg spasms, seems to help