I was on Tysabri for 1 1/2 years, I could feel it "running out" a few days before my scheduled infusion and then really tired for a couple of days after infusion (total of about 5 to 6 low days). I'm sorry to say that this never changed for me over the period of time I took it. I'm now on Tecfidera, not sure it benefits me as much as the Tysabri did but I don't have the medicine "running out" of my system feeling...feel more constant energy level.

I cannot help you. I take Copaxone and Ampyra along with a host of other meds for this crappy disease. Stay well. Peace, Mary Ann

Hi, I've had about seven infusions so far and generally feel better. I still find that I need to pace myself though. And, yes, I am exhausted, but I'm not sure it's from the infusion itself or just having an extra thing to do in a given week. This is especially true if I have other appointments or if things pick up at work in the same week. Good luck. I've also been on Copaxone and Tecfidera (which I hated because of the side effects). With Tysabri I haven't experienced any unbearable side effects.

Hi! I do the Tysabri Infusions. I was doing it for two years but went off of it for about a year until I found a different Neuro. Within that year I had a very bad relapse and tried Tecfidera but noticed no change. I have been on Tysabri again for eight months now. I have noticed a huge change. I can now walk a lot better (without a walker, some days a cane) I think it took about three or four treatments until I started noticing change. Yes, it makes me exhausted for a few days as well.
I hope Tysabri works for you. Best of luck ;)

Has anyone had any major improvements? Does one possible lesion on neck make you definitively an MS warrior?