No one should take Tec without being given the correct process.
1. Make a full meal with carbs and protein.
2. Take a baby asprin.
3. Eat your full meal.
4. Take Tec.
If you get itchy from Tec you can take a Benidryl. Doctors and pamphlets say it doesn't matter if you take with or without food- they're wrong and have no idea, don't listen to that.
My neuro says alcohol isn't supposed to be bad with Tec, but suggested not washing down Tec with a vodka just to be safe. I know Tec can effect the liver so I try to time it well and keep the drinking light.
I am better on Tec. Didn't happen right away, but after a year on Tec, some symptoms have lessened and my toe is finally no longer numb. :-)

Do not take Tecfidera on empty stomach.

I started Tecfidera 10 months ago. I had one spell of flushing that I recall in the beginning along with tummy ache too. The biggest issue I have is BM. I use to go #2 up to 3x a day. Now once a day if I'm lucky. Fiber in my smoothies (pills at night time) & healthy eating now; less dairy, gluten free, lots of water, little to no caffeine and flour & sugar substituted

Did any of you that switched to Tecfliferia feel better physically or see an improvement in your self. This is for anyone that switched from a previous drug.

For the first 10 months or so I was very strict about taking it every 12 hours. Then I read that if you take two at once by accident, you'll be fine, your symptoms will just be doubled up in a really uncomfortable way. After that I figured taking somewhere between 10-14 hours apart was probably fine, and now that I do that, it's still working great for me so I don't see any reason to think otherwise.