Couldn't do Tysabri since I tested JCV positive. Tecfedira stopped mobility in my legs. These Meds work differently on everybody. I've heard positive things about Rituximab.

I was on Tysabri for about 2 years and was coping well. I was then was found to have the JC virus. I was advised to 'jump off' so I did.
After much deliberation, I made my choice with the decision to keep hitting with full force, I didn't want to slide backwards....
I had my first Lemtrada infusion 'round' in April 2015 then a second 'cycle' in April 2016.
So far so good, but that is only my experience.

My daughter tried a few other medications with no luck. She had a second round of Lemtrada and just had a MRI done with no new or active lesions. Everything is very good. Thyroid went off alittle but no other side effects and don't have to take medications. First year took 5 days of treatment and second year took three days

I used Tysabri during Oct 2009 thru Feb 2014 and had zero, nada side effects; and it kept my MS symptoms stable with new lesions on brain. My neurologist took me off tysabri (via infusion) to try oral drug Tecfidera, which I used for 1.5 years with no problems and no side effects. Then starting Dec2015 until now I get infusion of Rituxan. RonGenser near Pittsburgh, PA

I did tysabri for 2 years. Loved it. Never felt better and had no side effects at all. In fact some of my lesions actually shrunk.