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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Increased Muscle Spasticity On Cymbalta (duloxetine)?

Increased Muscle Spasticity On Cymbalta (duloxetine)?

My primary care doctor recently added Cymbalta (duloxetine) 30mg to the 300mg Wellbutrin I'm already on because I've been experiencing worsened depression. My mood has improved however since starting the Cymbalta I've had increased muscle tightness, clonus/muscle spasms in my lower limbs (when I flex my foot), and stiff ankle joints. I've been on this antidepressant combination before but didn't have these issues nor have they been a recent feature of my MS. Does anyone else with MS on Cymbaltaread more

A MyMSTeam Member said:

Cymbalta helps my pain. Each of us is different

posted 3 months ago
A MyMSTeam Member said:

Take vitamin C---> 2,000 mg a day..vitamin c & d ...needs t/b taken w/ MS ---> working out defeats depression....

posted about 2 months ago
A MyMSTeam Member said:

I was on duloxetine for years but didn't see the need for it. Took myself off.

posted about 2 months ago
A MyMSTeam Member said:

Calcium..take calcium for muscle cramping .

posted 3 months ago
A MyMSTeam Member said:

my husband is on duloxetine he does not have MS he feels so much better.

posted 3 months ago
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