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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Increased Muscle Spasticity On Cymbalta (duloxetine)?

Increased Muscle Spasticity On Cymbalta (duloxetine)?

My primary care doctor recently added Cymbalta (duloxetine) 30mg to the 300mg Wellbutrin I'm already on because I've been experiencing worsened depression. My mood has improved however since starting the Cymbalta I've had increased muscle tightness, clonus/muscle spasms in my lower limbs (when I flex my foot), and stiff ankle joints. I've been on this antidepressant combination before but didn't have these issues nor have they been a recent feature of my MS. Does anyone else with MS on Cymbaltaread more

posted May 23 (edited)
A MyMSTeam Member

Cymbalta helps my pain. Each of us is different

posted May 29
A MyMSTeam Member

Take vitamin C---> 2,000 mg a day..vitamin c & d ...needs t/b taken w/ MS ---> working out defeats depression....

posted June 30
A MyMSTeam Member

I was on duloxetine for years but didn't see the need for it. Took myself off.

posted June 28
A MyMSTeam Member

Calcium..take calcium for muscle cramping .

posted June 3
A MyMSTeam Member

my husband is on duloxetine he does not have MS he feels so much better.

posted May 24

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MULTIPLE SCLEROSIS
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Most People With MS and Spasticity Report at Least 8 Additional Symptoms, Survey Finds

Most People With MS and Spasticity Report at Least 8 Additional Symptoms, Survey Finds

A MyMSTeam Member

MS spasticity is the culprit for my pain, by at least 80%. I've suffered chronic pain for about 15 years.

posted November 17

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