Is it safe for older people, specifically those over 65, to stop taking a disease-modifying therapy (DMT) for multiple sclerosis (MS)? Here are some considerations based on the context provided:
1. **Effectiveness of DMTs**: As people age, DMTs may become less effective. Clinical trials often exclude those over 55, making it Show Full Answer
Is it safe for older people, specifically those over 65, to stop taking a disease-modifying therapy (DMT) for multiple sclerosis (MS)? Here are some considerations based on the context provided:
1. **Effectiveness of DMTs**: As people age, DMTs may become less effective. Clinical trials often exclude those over 55, making it difficult to be certain of the effectiveness in older populations.
2. **Side Effects and Drug Interactions**: Older individuals are more likely to experience side effects from DMTs. They are also likely to be on multiple medications, which can lead to more drug interactions and potentially worsen outcomes.
3. **Stability of MS**: If an individual's MS has been stable for years, particularly in those with secondary progressive MS (SPMS), there might be a consideration to stop DMTs. Research suggests that people aged 70 or older with stable SPMS for at least two years have a high chance of not experiencing disease recurrences after discontinuing DMTs.
4. **Consultation with Healthcare Providers**: It's crucial for anyone considering stopping their DMT to discuss this decision with their MS specialist. Factors like past MRI results, current symptoms, and overall health should be considered in making a shared decision.
Each case is highly individualized, and the decision to stop a DMT should be made with careful consideration and consultation with healthcare providers.
April 27, 2024
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