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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 16, 2024
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A MyMSTeam Member

the thing with mavenclad it significantly decreases absolute lymphocytes 2 months to 3 months after the last dosage as designed and it takes a long time to increase back to normal
there is a mavenclad facebook group that is very active if you do facebook.

https://www.facebook.com/share/g/6PNEvH5hbGLyBP...

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August 16, 2024 (edited)
A MyMSTeam Member

My lymphocytes were dangerously low...... I got Covid then developed double pneumonia., once that cleared up, I had strep throat and a serious UTI!

August 16, 2024
A MyMSTeam Member

Thank you 😁

August 17, 2024
A MyMSTeam Member

just curious why he is changing?

August 16, 2024
MyMSTeam

Switching treatments can be a significant step in managing multiple sclerosis (MS). Here’s some information about both Zeposia and Mavenclad from your knowledge base:

Zeposia (Ozanimod)
- Usage: Approved by the FDA for treating relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS Show Full Answer

Switching treatments can be a significant step in managing multiple sclerosis (MS). Here’s some information about both Zeposia and Mavenclad from your knowledge base:

Zeposia (Ozanimod)
- Usage: Approved by the FDA for treating relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS).
- Mechanism: Zeposia works by preventing white blood cells from leaving the lymph nodes, reducing inflammation and protecting nerve cells.
- Administration: Taken orally in the form of hard gelatin capsules.
- Common Side Effects: Upper respiratory infection, elevated liver enzymes, low or high blood pressure, urinary tract infection, and back pain.
- Serious Side Effects: Liver damage, decline in pulmonary function, decreased heart rate, and macular edema.

Mavenclad (Cladribine)
- Usage: Approved by the FDA for treating adults with relapsing forms of MS, including RRMS and active SPMS. Typically prescribed when other treatments are ineffective or poorly tolerated.
- Mechanism: Mavenclad reduces the number of B and T lymphocytes, which are immune cells that contribute to autoimmune attacks in MS.
- Administration: Taken orally during two separate treatment courses each year, with each course lasting two weeks and about a month between courses.
- Common Side Effects: Headache, low white blood cell count, and upper respiratory tract infection.
- Serious Side Effects: Increased risk for low blood cell counts, serious infections, blood disorders, liver toxicity, and risk of developing graft-versus-host disease (GVHD) after blood transfusions.

Community Experience
- Zeposia: 51 people have indicated they have taken Zeposia.
- Mavenclad: Often used when other treatments are not effective or well-tolerated.

If you have any concerns or need more personalized advice, it’s always best to discuss them with your neurologist.

August 16, 2024

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