Switching treatments can be a significant step in managing multiple sclerosis (MS). Here’s some information about both Zeposia and Mavenclad from your knowledge base:
Zeposia (Ozanimod)
- Usage: Approved by the FDA for treating relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS Show Full Answer
Switching treatments can be a significant step in managing multiple sclerosis (MS). Here’s some information about both Zeposia and Mavenclad from your knowledge base:
Zeposia (Ozanimod)
- Usage: Approved by the FDA for treating relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS).
- Mechanism: Zeposia works by preventing white blood cells from leaving the lymph nodes, reducing inflammation and protecting nerve cells.
- Administration: Taken orally in the form of hard gelatin capsules.
- Common Side Effects: Upper respiratory infection, elevated liver enzymes, low or high blood pressure, urinary tract infection, and back pain.
- Serious Side Effects: Liver damage, decline in pulmonary function, decreased heart rate, and macular edema.
Mavenclad (Cladribine)
- Usage: Approved by the FDA for treating adults with relapsing forms of MS, including RRMS and active SPMS. Typically prescribed when other treatments are ineffective or poorly tolerated.
- Mechanism: Mavenclad reduces the number of B and T lymphocytes, which are immune cells that contribute to autoimmune attacks in MS.
- Administration: Taken orally during two separate treatment courses each year, with each course lasting two weeks and about a month between courses.
- Common Side Effects: Headache, low white blood cell count, and upper respiratory tract infection.
- Serious Side Effects: Increased risk for low blood cell counts, serious infections, blood disorders, liver toxicity, and risk of developing graft-versus-host disease (GVHD) after blood transfusions.
Community Experience
- Zeposia: 51 people have indicated they have taken Zeposia.
- Mavenclad: Often used when other treatments are not effective or well-tolerated.
If you have any concerns or need more personalized advice, it’s always best to discuss them with your neurologist.
August 16, 2024