The "crap gap" is a period between MS medication infusions when symptoms may temporarily worsen. It typically occurs in the days or weeks before your next scheduled infusion, as the medication starts to wear off. During this time, you might experience increased fatigue, brain fog, balance issues, and tingling sensations.
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The "crap gap" is a period between MS medication infusions when symptoms may temporarily worsen. It typically occurs in the days or weeks before your next scheduled infusion, as the medication starts to wear off. During this time, you might experience increased fatigue, brain fog, balance issues, and tingling sensations.
This phenomenon is not related to disease activity but rather to the timing of treatments. Some people may also notice symptoms immediately after an infusion, before the medication has had time to fully work in their system. Research suggests that factors like body weight may influence who experiences the crap gap. People with higher BMIs taking certain medications may be more likely to experience symptoms as they approach their next infusion. Additionally, the amount of medication binding to immune cells (receptor occupancy) can play a role in whether someone experiences these between-treatment symptoms.
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What Is the ‘Crap Gap’ Between MS Infusions?
April 12, 2025
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