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A MyMSTeam Member asked a question 💭
Clay Hill Florida
May 29
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A MyMSTeam Member

I don’t take Kesimpta, but I have read about the crap gap from it and Ocrevus . Hang there 🤗

May 29
A MyMSTeam Member

Good luck and try to stay strong. I take Tysabri and get the crap gap:

May 29
MyMSTeam

Are you wondering whether Kesimpta (ofatumumab) can cause the "crap gap"?

The crap gap is the period between MS medication doses when symptoms start to creep back in — things like fatigue, brain fog, balance issues, and tingling sensations. It's most commonly associated with infused DMTs, but Kesimpta is a self-injected Show Full Answer

Are you wondering whether Kesimpta (ofatumumab) can cause the "crap gap"?

The crap gap is the period between MS medication doses when symptoms start to creep back in — things like fatigue, brain fog, balance issues, and tingling sensations. It's most commonly associated with infused DMTs, but Kesimpta is a self-injected medication, which generally means a lower chance of experiencing it. That said, some people have reported experiencing crap gap symptoms with Kesimpta too. So while it's less common, it's not impossible.

If symptoms between doses are bothering you, here are some things to keep in mind:

- Talk to your neurologist — they may be able to suggest ways to manage symptoms like fatigue, brain fog, or tingling
- Never stop or switch your DMT without consulting your doctor first
- Crap gap symptoms don't necessarily mean your MS is getting worse — but they're still worth discussing

Staying honest with yourself and your care team about how you're feeling goes a long way! 💙

May 29
A MyMSTeam Member

I’m on Kesimpta for 1 1/2 years and have dealt with crap gap a few times. My specialty drug pharmacist said to take it every 28 days/4weeks and not do the every certain date of the month. It seems to be working better for me. Talk to your neurologist and pharmacist and get their input. Good luck. We are MS Strong 🧡💪🧡.

May 29
A MyMSTeam Member

One of the most useful things that the neurologist who first diagnosed me did was educate me on the need for me to switch things up to stay ahead of this disease. I would He used Ocrevis infusions to "arrest" (his term) my MS, but then after the first few years changed me over to the 3x weekly self injection of Rebif, followed by a change back to infusions of Briumvi. Even with the flushing period (crap gap) and the whole 'down days' of the infusion process, I think that it is much better than the multiple self injection per week option, especially given that prior to my DX I was a very regular blood donor, already very accustomed to being strapped up and the fluids piped, even though it was out rather than in... 🙂

June 1 (edited)

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