One of the main side effects of ocrelizumab (Ocrevus) is an increased risk of infections, particularly respiratory infections, urinary tract infections, and skin infections. Studies show that people taking ocrelizumab may have about twice the rate of serious infections compared to those on injectable MS therapies.
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One of the main side effects of ocrelizumab (Ocrevus) is an increased risk of infections, particularly respiratory infections, urinary tract infections, and skin infections. Studies show that people taking ocrelizumab may have about twice the rate of serious infections compared to those on injectable MS therapies.
This higher infection risk occurs because ocrelizumab is a high-efficacy disease-modifying therapy that works by suppressing parts of the immune system to reduce MS relapses and slow disease progression. Many people also experience what's known as the "crap gap" - a period when the medication starts wearing off before the next infusion. During this time, you might notice:
• Increased fatigue
• Brain fog or cognitive difficulties
• Balance problems
• Burning or tingling sensations
• General worsening of MS symptoms
These symptoms typically improve after receiving the next scheduled dose.
October 22, 2025
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