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Are you also on Ocrevus? Do you have any other conditions (sleep apnea, lung disease, etc)? Scheduled to have my first injection in a few weeks and the more I read about side effects, the more nervous I get.

November 12, 2025
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A MyMSTeam Member

I receive Botox every three months,past October was my fourth time getting it. Thigh and calf . I’ve experienced no issues.’ Right leg.

November 14, 2025
MyMSTeam

What side effects have people experienced with Botox for calf/hamstring spasticity?

It's completely understandable to feel nervous before trying a new treatment. Many MyMSTeam members have found Botox helpful for leg spasticity with manageable side effects.

The most common side effects people experience include
- Pain Show Full Answer

What side effects have people experienced with Botox for calf/hamstring spasticity?

It's completely understandable to feel nervous before trying a new treatment. Many MyMSTeam members have found Botox helpful for leg spasticity with manageable side effects.

The most common side effects people experience include:
- Pain and soreness at the injection site
- Temporary muscle weakness
- Flu-like symptoms
- Bruising, swelling, or infection at injection sites

Some members have shared positive experiences. One member said, "I get Botox every three months in my left leg to help with walking." Another noted, "I have regular Botox to help with problems in my foot/big toe. It's effective for a while but does wear off!"

The procedure itself typically takes 30-45 minutes as an outpatient treatment, with injections targeted to specific muscle groups causing spasticity. What are the rare but serious side effects to be aware of?

While Botox is generally considered safe, there are rare but serious side effects you should discuss with your doctor:
- Breathing problems
- Swallowing difficulties that may last for months
- Muscle weakness throughout the body
- Difficulty speaking
- Blurred or double vision

These serious effects can occur if the botulinum toxin spreads beyond the intended muscle group, happening within hours, days, or even weeks after injection.

Your doctor will carefully assess whether this treatment is right for you, especially considering your medical history and any other medications you're taking. Make sure to discuss all your concerns, including any other conditions you have, during your consultation.

November 12, 2025

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