What drugs can interfere with MS treatment?
Several types of medications can interact with disease-modifying therapies (DMTs) and potentially worsen MS symptoms or cause harmful side effects. Here are the main categories to be aware of:
Steroids
When combined with certain DMTs like natalizumab (Tysabri) or fingolimod Show Full Answer
What drugs can interfere with MS treatment?
Several types of medications can interact with disease-modifying therapies (DMTs) and potentially worsen MS symptoms or cause harmful side effects. Here are the main categories to be aware of:
Steroids
When combined with certain DMTs like natalizumab (Tysabri) or fingolimod (Gilenya), steroids can increase infection risk, especially with high doses or long-term use. Both medications weaken the immune system, making it harder to fight infections.
Antidepressants
Some antidepressants, particularly tricyclic antidepressants (TCAs), can worsen common MS symptoms and should generally be avoided unless absolutely necessary. Certain antidepressants like bupropion and TCAs may also increase seizure risk at high doses.
NSAIDs (like ibuprofen and naproxen)
These pain relievers can stress the liver when combined with DMTs like fingolimod, increasing the risk of liver damage. Long-term use can also cause digestive issues like ulcers or bleeding.
Anti-seizure drugs
Medications like gabapentin and pregabalin can cause significant drowsiness and worsen fatigue. They can also affect balance and coordination, increasing fall risk.
Anticholinergics
Used for bladder issues, these medications can cause memory problems and confusion, which may worsen cognitive symptoms already present in MS. Muscle relaxants
Baclofen and tizanidine can increase fatigue, weakness, and balance problems, especially when combined with DMTs.
Antihistamines
Common allergy medications can cause drowsiness and dizziness, worsening MS-related fatigue and balance issues. Some may also affect memory and concentration.
Wakefulness-promoting drugs
Medications like modafinil can increase cardiovascular side effects when combined with certain DMTs like fingolimod.
It's crucial to keep your healthcare team informed about all medications you're taking, including over-the-counter drugs and herbal supplements. Even natural supplements can interact with DMTs. Your doctor can help you weigh the benefits and risks of any medication combination and adjust your treatment plan accordingly.
January 9
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