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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 7
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A MyMSTeam Member

Thank you for your reply!

June 9
A MyMSTeam Member

I haven't taken Ponvory but, I have taken Zeposia which is also a S1P receptor modulator. I had no side effects while I was on it if I remember right you had to avoid certain foods while taking it. unfortunately, it failed for me but, that dose not mean it will for you.

June 9
MyMSTeam

Starting a new MS treatment can feel both exciting and nerve-wracking — totally understandable! Ponvory (ponesimod) belongs to a class of drugs called S1P receptor modulators, which work differently from Tecfidera, so the stomach issues you experienced may not follow you to this new medication.

S1P receptor modulators work Show Full Answer

Starting a new MS treatment can feel both exciting and nerve-wracking — totally understandable! Ponvory (ponesimod) belongs to a class of drugs called S1P receptor modulators, which work differently from Tecfidera, so the stomach issues you experienced may not follow you to this new medication.

S1P receptor modulators work by preventing certain immune cells (lymphocytes) from reaching the brain and spinal cord, which helps reduce MS attacks. Ponvory is approved for relapsing forms of MS, including:

- Clinically isolated syndrome (CIS)
- Relapsing-remitting MS (RRMS)
- Active secondary progressive MS (SPMS) Since Ponvory affects the immune system, it's worth being aware of a few potential risks, including a slightly increased chance of developing shingles. Let your neurologist know about any new or unusual symptoms after starting.

While there aren't specific MyMSTeam member stories about Ponvory to share right now, many members have navigated treatment switches and found relief from side effects by moving to a different class of medication. Wishing a smooth transition — here's to fewer stomach aches ahead! 🤞

June 7

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