MyMSTeam

It's completely understandable to feel nervous, especially when your MRI is showing significant changes and a new medication is being proposed. Those feelings are valid!

Yes, some MyMSTeam members who are JC+ have faced similar decisions about DMTs that carry PML risk. One member shared: "You have to ask yourself: Are the Show Full Answer

It's completely understandable to feel nervous, especially when your MRI is showing significant changes and a new medication is being proposed. Those feelings are valid!

Yes, some MyMSTeam members who are JC+ have faced similar decisions about DMTs that carry PML risk. One member shared: "You have to ask yourself: Are the chances of getting PML small enough that it outweighs the chances I may have another relapse which could cause permanent damage? To me, the answer is a resounding 'Yes!'"

That said, everyone's situation is different. Regarding Rituximab (you spelled it close enough! 😊) — yes, JC virus antibodies have been detected in people taking it, meaning PML risk exists. However, PML risk can be monitored and managed through:

- Regular blood tests to check JC virus antibody levels (typically every 6 months)
- Tracking antibody level changes over time
- Adjusting treatment plans based on those results

The key is that doctors don't just prescribe and disappear — there's ongoing monitoring involved. Regarding concerns about your neurologist — those are serious observations worth addressing. It may be worth considering a second opinion from another MS specialist before committing to a new treatment, especially given your MRI changes and the complexity of your situation.

When you do speak with your neuro, some good questions to ask include:

- What are my current JC antibody levels?
- How often will my levels be monitored on Rituximab?
- Why is Tecfidera no longer sufficient?
- What happens if insurance denies this too?

Trust your instincts — being an informed, active participant in your care really matters.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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