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Real members of MyMSTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
6 days ago
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MyMSTeam

What you're describing sounds like it could be the "crap gap" — a very real phenomenon that many people on infused DMTs experience. It refers to that window of time before your next infusion when the medication may be wearing off, causing MS symptoms to feel more intense or noticeable.

Common "crap gap" experiences Show Full Answer

What you're describing sounds like it could be the "crap gap" — a very real phenomenon that many people on infused DMTs experience. It refers to that window of time before your next infusion when the medication may be wearing off, causing MS symptoms to feel more intense or noticeable.

Common "crap gap" experiences include:

- Increased fatigue
- Worsening mobility or balance
- Feeling generally "off"
- Heightened anxiety or cognitive fog This doesn't necessarily mean your MS is poorly controlled — it can just be the natural ebb and flow of how the medication works in your body between doses.

That said, it's really important to let your neurologist know what you're experiencing. They can assess whether any adjustments are needed and help make sure you're as comfortable as possible leading up to your next infusion.

You're definitely not alone in this — many MyMSTeam members have shared similar experiences around infusion time.

6 days ago

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