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A MyMSTeam Member asked a question 💭
Melbourne, FL

I had been taking Aubagio from years but developed an issue with my liver. Now am changing medications and we are looking at either Kesimpta or Ocrevus. Just interested on thoughts, possible side effects and such
Thank you

July 20, 2023
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Reactions
A MyMSTeam Member

Kesimpta doesn't require expensive infusions and steroids to go with it. It's easy and only the first shot was bad for me. I like the idea having more frequent smaller doses as well.

July 25, 2023
A MyMSTeam Member

I've been taking Kesimpta since December 2023 and so far nothing has changed where my lesions are concerned and that was from last year's MRI results. I hope to get an MRI for this year set up on my neurologist visit in July. I feel good and am becoming more active. It works well for me .

June 18, 2024
A MyMSTeam Member

I keep seeing all the great reviews for Kesimpta, and I was so hoping it would work for me. It was my very first DMT, just started couple mths ago, but my body evidently had a severe reaction to it. Severe roof mouth burning, teeth pain, gums swelling and painful and tongue and cheek sores. And its still here 2 mths later. Having to decide on another treatment :( But MOST people I see think Kesimpta is just great, they have low side effects

August 22, 2025
MyMSTeam

Here's a comparison between Kesimpta and Ocrevus based on the information from the knowledge base:

Kesimpta (Ofatumumab)
- Type: Biologic immunomodulator, CD20-directed cytolytic antibody
- Mechanism: Reduces the number of CD20-positive B cells involved in relapsing multiple sclerosis.
- Administration: Injection under Show Full Answer

Here's a comparison between Kesimpta and Ocrevus based on the information from the knowledge base:

Kesimpta (Ofatumumab)
- Type: Biologic immunomodulator, CD20-directed cytolytic antibody.
- Mechanism: Reduces the number of CD20-positive B cells involved in relapsing multiple sclerosis.
- Administration: Injection under the skin using a single-use, prefilled pen or syringe.
- Common Side Effects:
- Headache
- Irritation at the injection site
- Injection-related reactions
- Upper respiratory tract infection
- Serious Side Effects:
- Opportunistic infections
- Fetal harm
- Precautions: Consult your doctor before receiving vaccines while taking Kesimpta.

Ocrevus (Ocrelizumab)
- Type: Biologic immunomodulator, genetically engineered antibody.
- Mechanism: Reduces the number of CD20-positive B cells involved in nerve cell attacks.
- Administration: Intravenous infusion in a medical setting once every six months after initial loading doses.
- Common Side Effects:
- Infusion reactions (headache, dizziness, fever, nausea, itching, rash, flushed skin, low blood pressure, fast heartbeat)
- Infections of the skin and respiratory tract
- Serious Side Effects:
- Severe infusion reactions
- Increased risk for some types of cancer

Summary
- Kesimpta is administered via subcutaneous injection, while Ocrevus is given through intravenous infusion.
- Both target CD20-positive B cells but have different administration schedules and side effect profiles.
- Kesimpta is more convenient for self-administration, whereas Ocrevus requires a medical setting for administration.

For more details, you can visit the respective pages:
- [Kesimpta](https://www.mymsteam.com/treatments/kesimpta)
- [Ocrevus](https://www.mymsteam.com/treatments/ocrevus)

July 14, 2024
A MyMSTeam Member

Well I just saw my dr today he’s trying to take me off Ocrevus and put me on vumerity or kesimta I was on Ocrevus since 2018

July 21, 2023

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