No I have been on Copaxone since 1997. You must really pay attention to where you do the shot and ensure you do not use the same spot. In you hip area you can draw a large grapefruit size circle on your hip area and any where in there do your shot. Copaxone should not make you feel like you have the flu at all. It maybe something that your body is getting used to the shots. I have never felt that feeling Copaxone has the least side effects. When you do your injections in the thighs you can you can use top and part of out thigh not inner thigh. Just look up on shared solutions site it will show you where to do the shots should that you are not bruising yourself. I do not use the auto injector so I can control the speed of the meds going in. By doing that no brusing or hurting. You can yous a heating pad on the injection after you have given it to yourself but do not rub it.