Yeah ... I ended up having mobility issues. I noticed my fatigue and symptoms were getting worse. I didn't realize it was the Tecfidera until my insurance company was jerking me around on a renewal, so I tapered off. I noticed improved mobility. Then went back on full dosage with decreased mobility again. I told my neuro and he said even though it isn't a listed side effect on the drug info that doesn't mean it doesn't happen. Anyway, waiting to see if I need to go on another medication. Crazy stuff these drugs. :-)

Oh yes, BIG time. I've always been a big water drinker, but now i just seriously can't get enough. i wake up dehydrated every morning even though I drink a lot every night and every time I wake up during the night. I use CBD oil for pain and it really works for me thankfully, so that aspect has not gotten worse on Tecfidera. I can get food related headaches too if I don't eat enough protein - more so now on Tecfidera. Hang in there! XX

I had to come off Tecfidera last July, after being on it for 20 months. After having the regular blood tests, I ended up with dangerously low levels of platelets and lymphocytes (white blood cells) - I’m now on Copaxone but I don’t like it - it hurts for the best part of an hour, after the injection, which I give myself 3 times a week.

I tried Tecfidera and had flushing and itching pretty bad that lasted about a day. I called the neuro and they said that I should stop taking it that I was having a reaction to it. They acted like it was a strange effect they hadn't seen before. Hope someone else can relate more of what you experienced.