Both Ampyra (dalfampridine) and baclofen are used in MS, but they work very differently and target different symptoms.
Ampyra (dalfampridine) is specifically approved to improve walking in people with MS. It works by helping nerve signals travel more effectively through damaged nerve fibers — think of it as boosting the Show Full Answer
Both Ampyra (dalfampridine) and baclofen are used in MS, but they work very differently and target different symptoms.
Ampyra (dalfampridine) is specifically approved to improve walking in people with MS. It works by helping nerve signals travel more effectively through damaged nerve fibers — think of it as boosting the electrical signal along a frayed wire.
Baclofen is a muscle relaxant that targets spasticity — the stiffness, tightness, and muscle spasms that MS can cause. It works like a "dimmer switch" on overactive nerve signals that make muscles tighten and spasm. Here's a quick side-by-side breakdown:
- Purpose: Ampyra improves walking ability; baclofen reduces muscle spasms and stiffness
- How it works: Ampyra improves nerve signal conduction; baclofen calms overactive nerve signals causing spasms
- Forms: Ampyra is an oral tablet; baclofen comes as tablets, liquid, or an implanted pump for severe spasticity
- Who should avoid it: Ampyra is not for people with a history of seizures or significant kidney problems; baclofen should be avoided during pregnancy and used cautiously with kidney issues
Always talk with your neurologist or healthcare provider before starting, stopping, or changing either medication, as both carry potential side effects and risks.
July 16
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